Human health risk assessment

We help clients make our world safer and healthier through human health analyses grounded in reliable research, transformational informatics, and proven technology.

Using the power of science to inform decisions and better protect public health

Our highly qualified, widely published experts collaborate to identify, collect, manage, evaluate, model, and interpret scientific data to produce broad-based analyses that stand up to intense scrutiny and establish a solid foundation for developing scientifically sound conclusions.

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Systematic literature review

Since 2014, we have assisted with over 60 systematic reviews for federal clients. We cover the life cycle and tailor our approach to the type of review, including searching, screening, extraction, quality review, and synthesis of scientific literature.

Environmental toxicology expertise

Our deep bench of Ph.D. toxicologists determine the quality of studies, weigh the evidence, perform benchmark dose modeling, and develop and implement physiologically-based pharmacokinetic (PBPK) models. They perform risk assessments for a wide range of substances, including hazard identification and dose-response assessment.

New approach methods

We offer support to transition away from animal testing methods through mechanistic analyses, QSAR models, and other in silico methods to understand the hazard potential of chemicals.

Epidemiology review

Our epidemiologists review, model, and interpret epidemiological evidence to support hazard conclusions and develop quantitative dose-response relationships. We perform meta-analyses and other statistical evaluations to determine the health effects of exposures.

Exposure assessment and modeling

Our exposure assessors use literature data, exposure models, and qualitative understanding to form chemical exposure conclusions for risk assessment. Our computational modelers build, validate, implement, maintain, and modernize the code base of a variety of exposure models, including those relied on for regulatory action.

Our services


  • Toxicology
  • Epidemiology
  • Exposure assessment
  • Library science
  • Data management
  • Dose-response evaluation


  • Peer review support
  • Workshop coordination
  • Science translation
  • Report publishing
  • Editing and formatting


  • Computational toxicology techniques
  • Machine learning and artificial intelligence
  • Exposure model development
  • Data visualization

Our technology

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Our work

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